How can digital data stored as DNA be manipulated?

DNA can be used to reliably store a vast amount of digital data. However, retrieval or manipulation of specific data encoded in these molecules has hitherto been difficult. Now, researchers from the CNRS, the ESPCI Paris-PSL and the University of Tokyo have pioneered the application of a new method that harnesses enzymes, offering initial clues as to how these technical obstacles may be overcome. Their findings are reported in Nature, the October 20, 2022.

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